The Joint 24th International Conference on Emerging Infectious Diseases in the Pacific Rim of the U.S.-Japan Cooperative Medical Sciences Program (USJCMSP) in collaboration with the 2nd International Symposium for Infectious Diseases Research Institutes Cooperation (IDRIC)
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Hepatitis Panel Agenda
Thursday| 7 March 2024 | DAY THREE
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8:30-8:40| Welcome and Introduction to the USJCMSP Hepatitis Panel | Tatsuya Kanto and Ray Chung
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TOPIC ONE: Progress in Development of New Therapies for Chronic HBV Infection and HBV+HDV co-infection
Moderator: Ray Chung & Takaji Wakita
8:40-8:55 | Structure of HBV preS1/NTCP Complex and its Implication to HBV Entry | Koichi Watashi, Japan
8:55-9:10 | Modeling Based Fitting of NTCP Empty Pocket Identify Novel Compounds as Potent Inhibitors of Hepatitis B Virus Entry | Kyun-Hwan Kim, Korea
9:10-9:25 | Biological Characterization of Various Hepatitis B Virus Strains Using Human Hepatocyte Chimeric Mice | Kazuaki Chayama, Japan
9:25-9:40 | Sustained Anti-viral and Anti-fibrotic Effect of HBV-specific Immune Modulator for Treatment of CHB Patients: Stoppage of NUCs in Sight | SF Akbar, Japan
9:40-9:55 | HBV Reactivation in HIV Patients After Withdrawal of anti-HBV Treatment | Hiroshi Yotsuyanagi, Japan
9:55-10:10 | HBV Immunity and the Path to Functional Cure | Georg Lauer, US
10:10-10:40 | Discussion for Talks 1-6
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10:40-11:00 | Coffee Break
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Moderators: Kyun-Hwan Kim & Kazyaki Chayama
11:00-11:15 | Viral Genome Analysis and in vitro Propagation of Genotrype1b HCV | Takaji Wakita, Japan
11:15-11:30 | Viral Hepatitis Elimination in Mongolia | Naranbaatar Dashdorji, Mongolia
11:30-11:45 | Epidemiological Study Towards Elimination of HBV and HCV | Junko Tanaka, Japan
11:45-11:55 | Young Investigator 1 | Targeting Capsid Forming Ability of Hepatitis B Virus Core Protein with Small-molecule Inhibitors | Chunkyu Ko, Korea
11:55-12:05 | Young Investigator 2 | Identification of Novel Cell Populations Associated with Liver Fibrosis in Hepatitis B | Masaya Sugiyama, Japan
12:05-12:15 | Young Investigator 3 | IFN-y Induced MHC Class II Transactivator as a Novel and Potent anti-HBV Factor | Mehrangiz Dezhbord, Korea
12:15-12:45 | Discussion for Talks 7-9
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12:45-13:45 | Lunch Break
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TOPIC TWO: Protective Immune Responses to HCV in Aid of Vaccine Development - Joint with Immunology Board
Moderators: Eui-Cheol Shin & Ken Ishii
13:45-14:00 | Lessons Learned from Natural Immunity and Hepatitis C Virus Vaccine Efficacy Trial | Andrea Cox, USA
14:00-14:15 | Interleukin-2 Produced by Type 2 Peripheral T Helper Cells Contribute to the Durability of Recall Antibody Responses | Masanori Isogawa, Japan
14:15-14:30 | Epigraphs, a strategy for vaccine design and potential application to HCV | Bette Korber, USA (Virtual)
14:30-14:45 | Effect of Pre-existing Immunity to Vaccine-induced Immune Responses | Hideki Ueno, Japan
14:45-15:00 | Yoshimasa Takahashi, Japan Immunology
15:00-15:15 | Bali Pulendran, USA
15:15-15:45 | Discussion of Talks 10-15
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15:45-16:15 | Break
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Moderatos: Georg Lauer & Yoshimasa Takahashi
16:15-16:30 | Liver Sinusoidal T Cells in Healthy and Pathologic Livers | Eui-Cheol Shin, Korea
16:30-16:45 | Involvement of Phospholipase A2 Induced by Hepatitis C Virus Infection in Hepatic Lipid Accumulation | Tetsuro Suzuki, Japan
16:45-17:00 | Vaccine Science and Design with DNA/RNA | Ken J. Ishii, Japan
17:00-17:15 | Neutralizing antibodies exploit vulnerable sites in HCV E2 and mediate spontaneous clearance of infection | Justin Bailey, USA
17:15-17:25 | Young Investigator 4 | CpG-ODN Mediated Immunophrophylaxis Against Viral Infection | Aska Tobuse, Japan
17:25-17:35 | Young Investigator 5 | Comprehensive Analysis of Immune Pathogenesis of Acute Hepatitis A with or without HIV Co-infection | Sachiyo Yoshio, Japan
17:35-17:45 | Young Investigator 6 | Regulatory T Cells After Successful Treatment of Chronic Hepatitis C | So-Young Kim, Korea
17:45-18:20 | Discussion for Talks 16-19
18:20 | Adjourn for the Day & Group Photo
19:00 |Speakers’ dinner (Hepatitis Panel, Immunology Board, Cancer Panel) Hosted by the Center for Viral Immunology, Korea Virus Research Institute @ Korean Restaurant Hanyang, Songdo, Incheon
Shuttle bus service is available.
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Friday| 8 March 2024 | DAY FOUR
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TOPIC 3: Hepatitis Virus-related and Non-viral Liver Cancer - Joint with Immunology Board and Cancer Panel
Moderators: Su-Hyung Park & Toru Kiyono
8:30-8:45 | Sera of Individuals Chronically Infected with Hepatitis B Virus (HBV) Contain Diverse RNA Types Produced by HBV Replication and Derived from Integrated HBV DNA | Severin Gudima, USA
8:45-9:00 | Long-read sequencing analysis of HBV genome integration in HCC | Tatsuhiro Shibata, Japan
9:00-9:15 | Regulatory Mechanism of Polycomb Repressive Complex 1 by HCV Infection | Kohji Moriishi, Japan
9:15-9:30 | ILT2 as a Regulator of NK Cells in Patients with HCC | Tatsuya Kanto, Japan
9:30-9:45 | Moleculat Landscape of Liver Cancer and Its Clinical Implications | Xin Wei Wang, USA
9:45-10:10 | Discussion for Talks 20-24
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10:10-10:50 | Coffee & Tea Break / Networking
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Moderator: Tatsuya Kanto
10:50-11:05 | 4-1BB Co-Stimulation, a Promising Strategy for Treating HCC | Su-Hyung Park, Korea
11:05-11:20 | mRNA-based T-cell Engineering for HBV-related HCC | Antonio Bertoletti, Singapore
11:20-11:35 | Ray Chung, USA
11:35-11:50 | Oxidative Stress Sensor Keap1 Recognixes HBx Protein to Activate the Nrf2/ARE Signaling Pathway, thereby Inhibiting Hepatitis B Virus Replication | Ikuo Shoji, Japan
11:50-12:05 | Epidemiology and Genomic Applications Detect Risk Factors and Discern Treatment Response in Liver Cancer | Anuradha Budhu, USA
12:05-12:30 | Discussion for Talks 25-29
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12:30-13:30 | Lunch Break
12:30-13:30 | Hepatitis Panel Business Meeting
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Moderators: Tatsuhiro Shubata & Xin Wei Wang
13:30-13:40 | Young Investigator 7 | Immune Resilience to Cancer by Repurposing Mycobacterium Tuberculosis-specific CD4 Memory Th1 Cells | Burcu Temizoz, Immunology
13:40-13:50 | Young Investigator 8 | Single Nanoparticle Mapping and Sorting in Biological Fluids and Breath Samples | Shuntaro Shimizu, Immunology
13:50-14:00 | Young Investigator 9 | A Novel Mechanism of Driving Intrahepatic Cholangiocarcinoma | Takahiro Kodama, Japan Hepatitis
14:00-14:10 | Young Investigator 10 | Differential T-cell and Monocyte Responses in Hepatocellular Carcinoma Treated with Regorafenib Plus Nivolumab | Hyung-Don Kum, Korea Hepatitis
14:10-14:20 | Young Investigator 11 | Laminin y2 Monomer, a Novel Biomarker for Hepatocellular Carcinoma in Patients with Chronic Hepatitis Virus Infection | Kouki Nio, Japan
14:20-14:30 | Young Investigator 12 | Role of Hepcidin Upregulation and Proteolytic Cleavage of Ferroportin 1 in Hepatitis C Virus-induced Iron Accumulation | Kazuyoshi Ohta, Japan Cancer
14:30-15:00 | Discussion for Young Investigators 7-12
15:00-15:15 | Wrap-up and Plans for a Report | Ray Chung & Tatsuya Kanto
15:15| Adjourn 37th Hepatitis / Immunology / Cancer Panel Meeting | Group Photo